کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849741 | 1561761 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genotoxicity evaluation of the flavonoid, myricitrin, and its aglycone, myricetin
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کلمات کلیدی
JECFAGLPFDAOECDEFSAMN-RETDNA damage - آسیبDNAEuropean Food Safety Authority - اداره ایمنی اروپاUS Food and Drug Administration - اداره غذا و داروی ایالات متحدهGood Laboratory Practice - تمرین خوب آزمایشگاهیRET - حقWorld Health Organization - سازمان بهداشت جهانیFood and Agriculture Organization of the United Nations - سازمان غذا و کشاورزی سازمان ملل متحدOrganization for Economic Cooperation and Development - سازمان همکاری های اقتصادی و توسعهGenotoxicity - سمیت ژنتیکیFAO - فائوFlavonoid - فلاونوئیدJoint FAO/WHO Expert Committee on Food Additives - مجمع متخصص FAO / WHO در مورد مواد افزودنی مواد غذاییMyricitrin - مریریکینMyricetin - میریستینmicronucleus or micronuclei - میکروسکوپ یا میکرونوکلئیکWHO - که
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Myricitrin, a flavonoid extracted from the fruit, leaves, and bark of Chinese bayberry (Myrica rubra SIEBOLD), is currently used as a flavor modifier in snack foods, dairy products, and beverages in Japan. Myricitrin is converted to myricetin by intestinal microflora; myricetin also occurs ubiquitously in plants and is consumed in fruits, vegetables, and beverages. The genotoxic potential of myricitrin and myricetin was evaluated in anticipation of worldwide marketing of food products containing myricitrin. In a bacterial reverse mutation assay, myricetin tested positive for frameshift mutations under metabolic activation conditions whereas myricitrin tested negative for mutagenic potential. Both myricitrin and myricetin induced micronuclei formation in human TK6 lymphoblastoid cells under conditions lacking metabolic activation; however, the negative response observed in the presence of metabolic activation suggests that rat liver S9 homogenate may detoxify reactive metabolites of these chemicals in mammalian cells. In 3-day combined micronucleus/Comet assays using male and female B6C3F1 mice, no induction of micronuclei was observed in peripheral blood, or conclusive evidence of damage detected in the liver, glandular stomach, or duodenum following exposure to myricitrin or myricetin. Our studies did not reveal evidence of genotoxic potential of myricitrin in vivo, supporting its safe use in food and beverages.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 83, September 2015, Pages 283-292
Journal: Food and Chemical Toxicology - Volume 83, September 2015, Pages 283-292
نویسندگان
Cheryl A. Hobbs, Carol Swartz, Robert Maronpot, Jeffrey Davis, Leslie Recio, Mihoko Koyanagi, Shim-mo Hayashi,