کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5850174 | 1561774 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oral toxicity evaluation of kefir-isolated Lactobacillus kefiranofaciens M1 in Sprague-Dawley rats
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کلمات کلیدی
GPTUrea-NNOAELγGTMCVMCHCINRMCHRBCSPSSWBCPBSCFUGRASAPTTRed blood cells - سلولهای قرمز خونALP - آلکالن فسفاتازAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییGOT - بدست آوردgenerally recognized as safe - به طور کلی به عنوان امن شناخته شده استactivated partial thromboplastin time - زمان ترومبوپلاستین جزئی فعال شده استToxicity - سمی بودنphosphate buffer saline - فسفات بافر شورmean cell volume - متوسط حجم سلولSprague–Dawley rat - موش Sprague-DawleySprague–Dawley rats - موش Sprague-DawleyInternational Normalized Ratio - نسبت عادی بین المللیno-observed-adverse-effect-level - هیچ نظارتی و معکوس-اثر-سطحcolony forming units - واحدهای تشکیل دهنده کلنیProbiotics - پروبیوتیکtotal protein - کل پروتئینgamma glutamyl transferase - گاما گلوتامیل ترانسفرازwhite blood cells - گلبول های سفید خونglutamate oxaloacetate transaminase - گلوتامات اگزالاکتات ترانس آمینازglutamic-pyruvic transaminase - گلوتامین-پریوویک ترانس آمیناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Oral toxicity evaluation of kefir-isolated Lactobacillus kefiranofaciens M1 in Sprague-Dawley rats Oral toxicity evaluation of kefir-isolated Lactobacillus kefiranofaciens M1 in Sprague-Dawley rats](/preview/png/5850174.png)
چکیده انگلیسی
Lactobacilli kefiranofaciens M1 has shown novel immunomodulation and anti-allergy probiotic attributes in cell and animal models. An acute oral toxicity assessment of L. kefiranofaciens M1 was evaluated in Sprague-Dawley rats. The rats were randomly assigned to four groups (12 rats/sex/group): the low dose group was orally gavaged with L. kefiranofaciens M1 at 3.0Â ÃÂ 108Â cfu/kg bw while the medium dose and high dose groups received 9.0Â ÃÂ 109Â cfu/kg bw and 1.8Â ÃÂ 1010Â cfu/kg bw, respectively, for 28Â days. The control group received phosphate buffer saline. The body weights were measured weekly while blood samples were collected for haematology and serum biochemistry tests. Histopathology of the organs (heart, liver, kidney, adrenal glands, spleen, ovary, testis), and urinalysis were conducted on study termination. The body weight gain of the L. kefiranofaciens M1 and control groups were comparable during the administration period. Overall, L. kefiranofaciens M1 did not induce adverse effects on haematology, serum biochemistry, and urinalysis parameters. Gross and microscopic histopathology of the organs revealed no toxicity effect of L. kefiranofaciens M1. In conclusion, 1.8Â ÃÂ 1010Â cfu/kg bw of L. kefiranofaciens M1 was considered as the no-observed-adverse-effect-level (NOAEL), which was the highest dose tested in the present study.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 70, August 2014, Pages 157-162
Journal: Food and Chemical Toxicology - Volume 70, August 2014, Pages 157-162
نویسندگان
E.E. Owaga, M.J. Chen, W.Y. Chen, C.W. Chen, R.H. Hsieh,