کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5850187 | 1561774 | 2014 | 9 صفحه PDF | دانلود رایگان |
- Exposure to the anti-cholinesterase pesticides altered energy metabolism and oxidative balance in the mice liver.
- Glucose, fat and protein metabolism in mice liver was disturbed by pesticides revealed by metabonomics.
- Dichlorvos (organophosphate) and malathion (organophosphate) produced additive toxicity in mice liver.
- Dichlorvos (organophosphate) and pirimicarb (carbamate) produced antagonistic toxicity in mice liver.
Organophosphorus (OP) and carbamate (CM) pesticides are widely used in agriculture. These pesticides are highly toxic to humans and their residues in food pose potential threat to human health. In this study, we investigated the effect of subchronic low-level exposure of OPs (dichlorvos, DDVP; malathion, MAL), CM pirimicarb (PI), or their mixtures (DDVPÂ +Â MAL, DDVPÂ +Â PI) on mice liver. Metabonomic analysis based on 1H nuclear magnetic resonance spectroscopy was carried out in combination with biochemical assays. Serum metabonomic analysis showed that levels of trimethylamine-N-oxide, lactate, acetone, very low- and low-density lipoprotein and 3-hydroxybutyrate changed after exposure to the pesticides. In the liver extracts, lactate, glucose, choline, glutathione, alanine, glutamine and isoleucine levels changed after the treatment by pesticides. Our results indicated that exposure to low dose DDVP, MAL and PI, either alone or in combination lead to alteration of liver glucose, fat and protein metabolism, energy metabolism and oxidative balance. This study also showed that metabonomics is of potential use in food toxicity study.
Journal: Food and Chemical Toxicology - Volume 70, August 2014, Pages 222-230