کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5850414 | 1561782 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genotoxic, antigenotoxic and phytochemical assessment of Terminalia actinophylla ethanolic extract
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کلمات کلیدی
NPDstandard cross2AFTPLTriphalaethylmethanesulfonateMitomycin CDHBAMMCMNNGEMS2-aminofluorene - 2-آمینوفلوئورن4-nitroquinoline-N-oxide - 4-نیتروکینولین-N-اکسید4NQO - 4NETOPCs - OPC هاAntigenotoxicity - آنتی ژنوتوکسیتیکTerminalia - ترمینالیاTAE - توSomatic Mutation and Recombination Test - جهش اجتماعی و تست بازتوزیعdihydroxybenzoic acid - دی هیدروکسی بنزوئیک اسیدGenotoxicity - سمیت ژنتیکیPlant extract - عصاره گیاهیLOH - لوهانDrosophila melanogaster - مگس سرکه، مگس میوهSMART - هوشمندانهOligomeric proanthocyanidins - پروانتوسایانیدینهای الیگومری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Terminalia actinophylla has been used for anti-diarrheic and haemostatic purposes in Brazil. The fly spot data obtained after exposure of marker-heterozygous Drosophila melanogaster larvae to T. actinophylla ethanolic extract (TAE) in the standard (ST) and high bioactivation (HB) crosses revealed that TAE did not induce any statistically significant increment in any spot categories. Differences between the two crosses are related to cytochrome P450 (CYPs) levels. In this sense, our data pointed out the absence of TAE-direct and indirect mutagenic and recombinagenic action in the Somatic Mutation and Recombination Test (SMART). When the anti-genotoxicity of TAE was analyzed, neither mitomycin C (MMC) nor ethylmethanesulfonate (EMS) genotoxicity was modified by the post-exposure to TAE, which suggests that TAE has no effect on the mechanisms involved in the processing of the lesions induced by both genotoxins. In the mwh/flr3 genotype, co-treatment with TAE may lead to a significant protection against the genotoxicity of MMC and a weak but significant effect in the toxic genetic action of EMS. The overall findings suggested that the favorable modulations by TAE could be, at least in part, due to its antioxidative potential.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 62, December 2013, Pages 521-527
Journal: Food and Chemical Toxicology - Volume 62, December 2013, Pages 521-527
نویسندگان
P.F.M.R. Pádua, R.R. Dihl, M. Lehmann, B.R.R. de Abreu, M.F. Richter, H.H.R. de Andrade,