Keywords: Paper mill effluents; Endocrine-disrupting compounds; Cytotoxicity; Genotoxicity; AFB1; aflatoxin B1; AOX; adsorbable organic halogen compounds; BaP; benzo [a] pyrene; BBP; benzyl butyl phthalate; BEHP; bis(2-ethylhexyl) phthalate; BOD; biochemical oxygen
مقالات ISI (ترجمه نشده)
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Keywords: LS; Lynch syndrome; CRC; colorectal cancer; HNPCC; hereditary non-polyposis colon cancer; MMR; mismatch repair; FAP; familial adenomatous polyposis; CFS; cancer family syndrome; MSI; microsatellite instability; IDL; insertion/deletion loop; MSH2; human mu
Keywords: Gentiana lutea extract; 6-Gingerol; MNNG; DMBA; HepG2; Micronuclei;
Keywords: CRISPR; clustered regularly interspaced short palindromic repeats; DSB; double stranded break; EMS; ethyl methane sulfonate; EPA; eicosapentaenoic acid; GMO; genetically modified organism; MNNG; methylnitronitrosoguanidine; TAG; triacylglycerol; TALEs; tr
Keywords: Colon Cancer; Functional Tests; Predisposition; Tumor; 6-TG; 6-thioguanine; CMMRD; constitutional mismatch repair; evMSI; ex vivo microsatellite instability; FAP; familial adenomatous polyposis; gMSI; germline microsatellite instability; IHC; immunohisto
Keywords: AD; adaptation dose; AR; adaptive response; CA; chromosomal aberrations; CD; challenge dose; CFU-BM; colony forming units in bone marrow; DOX; doxorubicin; GSM; Global System for Mobile Communications; GTEM; Gigahertz Transverse Electromagnetic; MMP; mito
Keywords: MNNG; N-methyl-Nâ²-nitro-N-nitrosoguanidine; LNT; linear no-threshold; 6-TG; 6-thio-guanine; GST-P; glutathione S-transferase placental; ROS; reactive oxygen species; ICH; International Conference on Harmonisation of Technical Requirements for Registrati
Functional role of lncRNA LOC101927497 in N-methyl-Nâ²-nitro-N-nitrosoguanidine-induced malignantly transformed human gastric epithelial cells
Keywords: Gastric cancer; LOC101927497; Long non-coding RNA; Chemical carcinogenesis; MNNG;
Old and new glycopeptide antibiotics: From product to gene and back in the post-genomic era
Keywords: Glycopeptide antibiotics; Vancomycin; Teicoplanin; A40926; Dalbavancin; Natural product screening; Strain improvement; Fermentation; Genetic engineering; Combinatorial biochemistry; Dahp; 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase; Atf; acyltran
Cytotoxic effect of Kalanchoe flammea and induction of intrinsic mitochondrial apoptotic signaling in prostate cancer cells
Keywords: 2AA; 2-aminoanthracene; 4NQO; 4-nitroquinoline; BCA; bicinchoninic acid; Bcl-2; B-cell lymphoma 2; CA; coumaric acid; CAD; caspase-activated dnase; DAPI; 4',6-diamidino-2-phenylIndole; DCF; oxidize 2'-7'-dichlorodihydrofluorescein; DCFH; reduced 2â
ReviewRegulation of DNA damage tolerance in mammalian cells by post-translational modifications of PCNA
Keywords: TLS; translesion synthesis; PCNA; proliferating cell nuclear antigen; Polη; DNA polymerase eta; HU; hydroxyurea; SUMO; small ubiquitin-related modifier; ISG15; interferon-stimulated gene 15; UV; ultraviolet; MNNG; N-methyl-N'-nitro-N-nitrosoguanidine;
A novel RIPK1 inhibitor that prevents retinal degeneration in a rat glaucoma model
Keywords: CH; chemical hypoxia; CHX; cycloheximide; Cpd27; compound 27; DAPI; 4,6-diamidino-2-phenylindole; GCL; ganglion cell layer; H2O2; hydrogen peroxide; MNNG; 1-methyl-3-nitro-1 nitrosoguanidine; Nec-1; necrostatin-1; OGD; oxygen glucose deprivation; PI; prop
Measurement of O6-alkylguanine-DNA alkyltransferase activity in tumour cells using stable isotope dilution HPLC-ESIâ¿¿MS/MS
Keywords: AGT; O6-alkylguanine-DNA alkyltransferase; HPLC-ESIâ¿¿MS/MS; high-performance liquid chromatography electrospray ionization tandem mass spectrometry; O6-BG; O6-benzylguanine; Cys145; Cysteine 145; O6-MG; O6-methylguanine; [3H]MNU; N-[3H]-methyl-N-nitrosou
Targeting DNA mismatches with rhodium metalloinsertors
Keywords: MMR; mismatch repair; DHFR; dihydrofolate reductase; EGFR; epidermal growth factor receptor; PCNA; proliferating cell nuclear antigen; chrysi; 5,6-chrysene quinone diimine; bpy; 2,2â²-bipyridine; ELISA; enzyme-linked immunosorbent assay; MNNG; N-methyl-N
Evaluation of role of telmisartan in combination with 5-fluorouracil in gastric cancer cachexia
Keywords: QoL; quality of life; PPARγ; peroxisome proliferator activated receptor gamma; RAAS; renin angiotensin aldosterone system; VSMC; vascular smooth muscle cell; 5-FU; 5-Flourouracil; MNNG; N-methyl-Nâ²-nitro-N-nitrosoguanidine; VLDL; very low density lipop
Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents
Keywords: AAG; alkyladenine DNA glycosylase; ATM; ataxia telangiectasia mutated; BER; base excision repair; BPD; break point dose; BMD; benchmark dose; BMDL; benchmark dose lower confidence limit; CSBP; computational systems biology pathway; DSB; double strand brea
ATR-CHK1-E2F3 signaling transactivates human ribonucleotide reductase small subunit M2 for DNA repair induced by the chemical carcinogen MNNG
Keywords: Human ribonucleotide reductase small subunit M2 (RRM2); E2F3; Transcriptional regulation; MNNG; DNA repair;
Gleditsia species: An ethnomedical, phytochemical and pharmacological review
Keywords: AFGS; the ethanol extract from the anomalous fruits of Gleditsia sinensis Lam.; ALI; acute lung injury; AML; acute myelogenous leukemia; AP-1; activator protein-1; ARDS; acute respiratory distress syndrome; bFGF; basic fibroblast growth factor; CDK; cycli
The organophosphate insecticide chlorpyrifos confers its genotoxic effects by inducing DNA damage and cell apoptosis
Keywords: Chlorpyrifos; O,Oâ²-diethyl-O-3,5,6-trichloro-2-pyridyl phosphorothionate; OPs; organophosphorus insecticide; MNNG; N-methyl-Nâ²-nitro-N-nitrosoguanidine; LMA; low melting-point agarose; NMPA; normal melting-point agarose; DAPI; 4â²,6-diamidino-2-pheny
ARTD1 (PARP1) activation and NAD+ in DNA repair and cell death
Keywords: NAD+; ADP(ribosyl)ation; Energy depletion; Metabolic defects; AMP; adenine monophophate; ARTD; ADP-ribosyltransferase diphtheria toxin-like; HK1; hexokinase 1; NAD; nicotinamide andenine dinucleotide; Nam; nicotinamide; NR; nicotinamide riboside; Na; nico
miR-21 regulates N-methyl-N-nitro-N′-nitrosoguanidine-induced gastric tumorigenesis by targeting FASLG and BTG2
Keywords: Gastric cancer; MicroRNA; miR-21; MNNG; Tumorigenesis
PARP-1 activation causes neuronal death in the hippocampal CA1 region by increasing the expression of Ca2Â +-permeable AMPA receptors
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AP5; 2-amino-5-phosphonopentanoate; AMPK; 5ⲠAMP-activated protein kinase; AIF; apoptosis-inducing factor; Cyt-C; cytochrome-C; JNK; Jun N-terminal kinase; GluA1; glutamate AMPA receptor subun
Energy adaptive response during parthanatos is enhanced by PD98059 and involves mitochondrial function but not autophagy induction
Keywords: 3AB; 3-aminobenzamide; 7AAD; 7-aminoactinomycin D; AIF; apoptosis-inducing factor; AMPK; AMP-activated protein kinase; DPI; diphenyliodonium; DXR; doxorubicin; FACS; fluorescence-activated cell sorting; FCCP; trifluorocarbonylcyanide phenylhydrazone; LC3;
Genotoxic, antigenotoxic and phytochemical assessment of Terminalia actinophylla ethanolic extract
Keywords: 2AF; 2-aminofluorene; DHBA; dihydroxybenzoic acid; EMS; ethylmethanesulfonate; HB; high bioactivation cross; LOH; loss of heterozygosis; MMC; mitomycin C; MNNG; N-methyl-Nâ²-nitro-nitrosoguanidine; 4NQO; 4-nitroquinoline-N-oxide; NPD; 4-nitro-o-phelylene
An HPLC-tandem mass spectrometry method for simultaneous detection of alkylated base excision repair products
Keywords: 3mA; N3-methyladenine; 7mG; N7-methylguanine; 1mA; N1-methyladenine; εA; 1,N6-ethenoadenine; MAG; methyladenine DNA glycosylase; TAG; E. coli 3-methyladenine DNA glycosylase I; AlkA; E. coli 3-methyladenine DNA glycosylase II; AAG; human alkyladenine DNA
Docosahexaenoic acid and tetracyclines as promising neuroprotective compounds with poly(ADP-ribose) polymerase inhibitory activities for oxidative/genotoxic stress treatment
Keywords: Oxidative stress; Genotoxic stress; DHA; Tetracyclines; MNNG; Neuronal cell death;
Crosstalk between apoptosis, necrosis and autophagy
Keywords: AIF; Apoptosis Inducing Factor; AMPK; Adenosine Monophosphate activated Kinase; APAF1; Apoptotic Protease Activating Factor 1; BCL-2; B-cell lymphoma 2; BCL-Xl; B-cell lymphoma extra large; BEC1; Beclin-1; BH; Bcl-2 homology; cIAP1; cellular inhibitor of
N-methyl-N-nitro-N-nitrosoguanidine-mediated ING4 downregulation contributed to the angiogenesis of transformed human gastric epithelial cells
Keywords: MNNG; Transformed gastric epithelial cells; Angiogenesis; ING4; NF-κB;
Effect of blueberries (BB) on micronuclei induced by N-methyl-Nâ²-nitro-N-nitrosoguanidine (MNNG) and 7,12-dimethylbenz(a)anthracene (DMBA) in mammalian cells, assessed in in vitro and in vivo assays
Keywords: Blueberries; Micronucleus assay; MNNG; DMBA; HepG2; Mice bone marrow;
Optimization extraction of Ganoderma lucidum polysaccharides and its immunity and antioxidant activities
Keywords: MNNG; Gastric cancer; Antioxidant; Immunity; Ganoderma lucidum polysaccharides
Protective effect of ellagic acid (EA) on micronucleus formation induced by N-methyl-Nâ²-nitro-N-nitrosoguanidine (MNNG) in mammalian cells, in in vitro assays and in vivo
Keywords: Ellagic acid; Micronucleus assay; MNNG; HepG2; Bone marrow;
A comparative study of the anticlastogenic effects of chlorophyllin on N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) or 7,12-dimethylbenz (α) anthracene (DMBA) induced micronuclei in mammalian cells in vitro and in vivo
Keywords: Chlorophyllin; Micronucleus assay; MNNG; DMBA; HepG2; Bone marrow
Heterologous production and characterisation of two distinct dihaem-containing membrane integral cytochrome b561 enzymes from Arabidopsis thaliana in Pichia pastoris and Escherichia coli cells
Keywords: Ax; absorption at a wavelength of x nm; BCA; bicinchoninic acid; BMGY; buffered glycerol-complex medium; BMMY; buffered methanol-complex medium; BSA; bovine serum albumin; CV; column volumes; CYBASC; cytochrome b561 ascorbate reducible family; cyt b561; c
Using mice to unveil the genetics of cancer resistance
Keywords: AC; adenocarcinoma; AOM; azoxymethane; APC; antigen-presenting cells; BH; BCL2 homology; CCl4; carbon tetrachloride; cM; centimorgan; COX; cyclo-oxygenase; CTLA-4; cytotoxic T-lymphocyte antigen 4; DC; dendritic cells; DEN; diethylnitrosamine; DMBA; 7,12-
Systematics and health effects of chemically distinct tannins in medicinal plants
Keywords: ACTH; adrenocorticotropic hormone; ADP; adenine 5â²-diphosphate; AIBN; 2,2â²-azobisisobutyronitrile; B[a]p diol epoxide; ±7β 8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; DHHDP; dehydrohexahydroxydiphenoyl; DMBA; 7,12-dimethylbenz[a]
Use of the in vivo skin comet assay to evaluate the DNA-damaging potential of chemicals applied to the skin
Keywords: MNNG; N-methyl-Nâ²-nitro-N-nitrosoguanidine; 4NQO; 4-nitroquinoline-1-oxide; MMC; mitomycinC; B[a]P; benzo[a]pyrene; DMBA; 7,12-dimethylbenz[a]anthracene; ROS; reactive oxygen species; UDS; unscheduled DNA synthesis; Epidermal; Skin comet assay; Hairless
In vitro Mutagen binding and antimutagenic activity of human Lactobacillus rhamnosus 231
Keywords: Acridine orange; Antimutagens; Biotransformation; Detoxification; Lactobacillus rhamnosus; MNNG; MeIQX
Ex vivo detection of histone H1 modified with advanced glycation end products
Keywords: CML; Nε-carboxymethyllysine; AGE; advanced glycation end product; MNNG; N-methyl-Nâ²-nitro-N-nitrosoguanidine; PARG; poly(adenosine diphosphoribose) glycohydrolase; PARP; poly(adenosine diphosphoribose) polymerase; PCA; perchloric acid; TCA; trichloroac
Oral subchronic and genotoxicity studies conducted with the amino acid, l-glutamine
Keywords: AF-2; 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide; BP; 3,4-benzo[a]pyrene; CHL/IU; Chinese hamster lung; CMC; carboxymethylcellulose; MNNG; 1-methyl-3-nitro-1-nitrosoguanidine; NOAEL; no-observed-adverse-effect-level; Glutamine; Toxicity; Safety; Oral; Diet
A Noninvasive Method for Early Detection of MNNG-Induced Gastric Cancer of Male Wistar rat: Ultrasonic Study
Keywords: Gastric cancer; Noninvasive method; Cancer detection; Ultrasound; Animal model of cancer; MNNG;
Time-series analysis of gene expression profiles induced by nitrosamides and nitrosamines elucidates modes of action underlying their genotoxicity in human colon cells
Keywords: CCR; colorectal cancer; GEO; Gene Expression Omnibus; MIF; macrophage migration inhibitory factor; MNNG; N-methyl-N'-nitro-N-nitrosoguanidine; MNU; N-methyl-N-nitrosurea; NDEA; N-nitrosodiethylamine; NDMA; N-nitrosodimethylamine; NOCs; N-nitroso compoun
Phosphorylated c-Jun and Fra-1 induce matrix metalloproteinase-1 and thereby regulate invasion activity of 143B osteosarcoma cells
Keywords: AP-1; activator protein-1; CXCR4; C-X-C chemokine receptor type 4; ECM; extracellular matrix; ELISA; enzyme-linked immunosorbent assay; EMSA; electrophoretic mobility shift assay; ERK; extracellular signal-regulated kinase; ETS; E-twenty six; FCS; fet
Early lesions induced in rat colon epithelium by N-methyl-N′-nitro-N-nitrosoguanidine
Keywords: MNNG; Rat; Colon; Carcinogenesis; M1/MUC5AC mucin; Aberrant crypt foci
Syrian Hamster Embryo (SHE) cell transformation assay with and without X-ray irradiation of feeder cells using Di(2-ethylhexyl)phthalate (DEHP) and N-nitroso-N-methylnitroguanidine (MNNG)
Keywords: SHE cell transformation assay; Conditioned media; Without X-ray irradiation; MNNG; DEPH; Syrian Hamster Embryo;
Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG
Keywords: Angiogenesis; Apoptosis; Chemoprevention; Eugenol; Invasion; MNNG
p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1
Keywords: p21CDKN1A; PARP-1; Base excision repair; PCNA; MNNG
N-methyl-N′-nitro-N-nitrosoguanidine induces and cooperates with 12-O-tetradecanoylphorbol-1,3-acetate/sodium butyrate to enhance Epstein-Barr virus reactivation and genome instability in nasopharyngeal carcinoma cells
Keywords: EBV, Epstein-Barr virus; NPC, Nasopharyngeal carcinoma; SB, Sodium butyrate; MNNG, N-methyl-N′-nitro-N-nitrosoguanidine; TPA, 12-O-tetradecanoylphorbol-1,3-acetateEpstein-Barr virus; Genome instability; MNNG; Viral reactivation
Regulation of poly(ADP-ribose) polymerase-1 functions by leukocyte elastase inhibitor/LEI-derived DNase II during caspase-independent apoptosis
Keywords: AIF; apoptosis-inducing factor; BHK; Baby Hamster Kidney; CAD; caspase-activated DNase; LEI; leukocyte elastase inhibitor; L-DNase II; LEI-derived DNase II; MEF; mouse embryonic fibroblasts; MNNG; N-methyl-Nâ²-nitro-N-nitrosoguanidine; PAR; poly-ADP-ribo
Mismatch repair in Trypanosoma brucei: Heterologous expression of MSH2 from Trypanosoma cruzi provides new insights into the response to oxidative damage
Keywords: MNNG; N-methyl-Nâ²-nitro-N-nitrosoguanidine; MMR; mismatch repair; H2O2; hydrogen peroxide; 8oxoG; 7,8-dihydro-8-oxoguanine; RT-PCR; reverse trancriptase PCR; MTT; methylthiazoldiphenyltetrazolium bromide; DNA repair; Hydrogen peroxide; Trypanosomatids;
DNA mismatch repair-induced double-strand breaks
Keywords: DNA mismatch repair; Double-strand breaks; Recombination; Cisplatin; MNNG