کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5850469 | 1561782 | 2013 | 7 صفحه PDF | دانلود رایگان |

- Cancer risk from daily intake of LMG was estimated first time.
- Probabilistic risk assessment was conducted for LADD and MOE.
- Results of both cancer risk and margin of exposure are comparable.
- Older people could be at greater risk of exposure to LMG in Taiwan.
To assess the potential risk of human exposure to carcinogenic leucomalachite green (LMG) due to fish consumption, the probabilistic risk assessment was conducted for adolescent, adult and senior adult consumers in Taiwan. The residues of LMG with the mean concentration of 13.378 ± 20.56 μg kgâ1 (BFDA, 2009) in fish was converted into dose, considering fish intake reported for three consumer groups by NAHSIT (1993-1996) and body weight of an average individual of the group. The lifetime average and high 95th percentile dietary intakes of LMG from fish consumption for Taiwanese consumers were estimated at up to 0.0135 and 0.0451 μg kg-bwâ1 dayâ1, respectively. Human equivalent dose (HED) of 2.875 mg kg-bwâ1 dayâ1 obtained from a lower-bound benchmark dose (BMDL10) in mice by interspecies extrapolation was linearly extrapolated to oral cancer slope factor (CSF) of 0.035 (mg kg-bwâ1 dayâ1)â1 for humans. Although, the assumptions and methods are different, the results of lifetime cancer risk varying from 3 Ã 10-7 to 1.6 Ã 10-6 were comparable to those of margin of exposures (MOEs) varying from 410,000 to 4,800,000. In conclusions, Taiwanese fish consumers with the 95th percentile LADD of LMG have greater risk of liver cancer and need to an action of risk management in Taiwan.
Journal: Food and Chemical Toxicology - Volume 62, December 2013, Pages 770-776