کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5851588 1561789 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Catechins are not major components responsible for the beneficial effect of Camellia sinensis on the ovarian δ-ALA-D activity inhibited by cadmium
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Catechins are not major components responsible for the beneficial effect of Camellia sinensis on the ovarian δ-ALA-D activity inhibited by cadmium
چکیده انگلیسی

Cadmium has been associated with a wide spectrum of deleterious effects on the reproductive tissues, including ovary. This investigation evaluated the protective role of Camellia sinensis (green, white and red teas) in the cadmium-induced inhibition of ovarian δ-aminolevulinate dehydratase (δ-ALA-D) activity in vitro and ex vivo. This study demonstrated that green and white teas restored the cow ovary δ-ALA-D activity inhibited by cadmium whereas red tea had no effect in vitro. In addition, green tea was able to restore enzyme activity inhibited after acute cadmium exposure in mice ovary. Teas infusions composition was assessed by HPLC in a quantitative assay for catechins, purine alkaloids and gallic acid as well as total polyphenol content. The greatest effect of green tea observed in vitro as well as the protective role presented in the ex vivo study could be attributed to the major content of phenols, but not catechins. In fact, catechins were not able to restore enzyme activity inhibited by cadmium, demonstrating that these compounds are not major components responsible for the beneficial effect of green tea observed in this study. This study demonstrated the helpful effect of green tea infusion in ameliorating a marker protein of cadmium intoxication in ovarian tissue.

Highlights► Green and white teas restored ovary δ-ALAD activity inhibited by Cd in vitro. ► Green tea reverses ovarian δ-ALAD activity inhibited by Cd both in vitro and ex vivo. ► The beneficial effect of green tea may be related with phenols but not catechin content. ► Catechins were not able to restore enzyme activity inhibited by cadmium. ► Catechins are not major components responsible for the beneficial effect of green tea on ovarian δ-ALAD activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 55, May 2013, Pages 463-469
نویسندگان
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