کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5851684 | 1561786 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of Korean pear (Pyruspyrifolia cv. Shingo) juice on hangover severity following alcohol consumption
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کلمات کلیدی
MDATBARFLPIRBALDH2AUC - AUCPCA - PCAThiobarbituric acid - اسید تیوباربیتوریکPerchloric acid - اسید پرکلریکAlcohol - الکلHangover - خماریPharmacodynamics - فارماکودینامیکpharmacokinetic - فارماکوکینتیکPharmacokinetics - فارماکوکینتیکmalondialdehyde - مالون دی آلدهیدAreas under the curve - مناطق تحت منحنیinstitutional review board - هیئت بررسی نظارتrestriction fragment length polymorphism - پلی مورفیسم طول قطعه قطعه
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Korean pear has been used as a traditional prophylactic agent for alcohol hangover. However, its mechanism was not investigated in human yet. Therefore, we performed a randomized single blind crossover trial with 14 healthy young men to examine effects of Korean pear juice on alcohol hangover. All subjects consumed 540 ml of spirits (alcohol conc. 20.1 v/v%) after 30 min from the intervention, i.e. placebo or Korean pear juice treatment. Blood and urine specimens were collected in time-courses (9 time-points for 15 h after alcohol consumption). The total and average of hangover severity were alleviated to 16% and 21% by Korean pear juice at 15 h after the alcohol consumption, respectively (ps < 0.05). Particularly, 'trouble concentrating' was significantly improved by the pear juice treatment (p < 0.05). Impaired memory, and sensitivity to light and sound were significantly improved by Korean pear juice among the subjects with ALDH2*1/*1 or ALDH2*1/*2 genotypes (ps < 0.05) but not in the subjects with ALDH2*2/*2 genotype. In addition, the pear juice treatment lowered levels of blood alcohol (p < 0.01). Therefore, Korean pear juice may alleviate alcohol-hangover and its detoxification of alcohol seems to be modified by the genetic variation of ALDH2.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 58, August 2013, Pages 101-106
Journal: Food and Chemical Toxicology - Volume 58, August 2013, Pages 101-106
نویسندگان
Ho-Sun Lee, Toyohi Isse, Toshihiro Kawamoto, Hyun Wook Baik, Jong Y. Park, Mihi Yang,