Water extracts of tree Hypericum sps. protect DNA from oxidative and alkylating damage and enhance DNA repair in colon cells

► Diet is an important contributing factor for cancer risk. ► Hypericum water extracts possess antigenotoxic properties. ► Hypericum protects colon cells from oxidative and alkylating DNA damage. ► Hypericum increase alkylating DNA damage repair activity by BER pathway. ► The antigenotoxic effects of Hypericum sp. may contribute to colon cancer prevention.