Pioglitazone protects against cisplatin induced nephrotoxicity in rats and potentiates its anticancer activity against human renal adenocarcinoma cell lines

► Pioglitazone protects against cisplatin -induced nephrotoxicity in rats. ► This effect may be mediated by reduction in oxidative stress and inflammation. ► Pioglitazone potentiates the cytotoxic effect of cisplatin against cancer cells.