An innovative approach to the safety evaluation of natural products: Cranberry (Vaccinium macrocarpon Aiton) leaf aqueous extract as a case study

► Natural products are challenging to characterize for a safety evaluation. ► Natural variability of key components must be understood for safety and quality. ► Pharmacognosy aids in identifying compound classes that may be present in a plant. ► We have developed an innovative approach for safety evaluation of natural products.