کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5852238 | 1130848 | 2012 | 8 صفحه PDF | دانلود رایگان |
The genetically-modified (GM) soybean 3Ã5423Â ÃÂ 40-3-2 expresses siRNA for the fatty acid desaturase-2 enzyme which results in higher concentrations of oleic acid (18:1) relative to linoleic acid (18:2) compared with non-GM soybeans. It also expresses the CP4 EPSPS protein for tolerance to glyphosate. In this study, three different dietary concentrations (7.5%, 15% and 30% wt/wt) of 3Ã5423Â ÃÂ 40-3-2 or non-GM soybeans were fed to Sprague-Dawley rats for 90Â days during which in-life nutritional and growth performance variables were evaluated followed by analysis of standard clinical chemistry, hematology and organ variables. Compared with rats fed the non-GM control diet, some statistically significant differences were observed in rats fed the 3Ã5423Â ÃÂ 40-3-2 diet. However the differences were not considered treatment-related and commonly fell within the normal ranges of the control group consuming the commercial diet. These results demonstrated that the GM soybean 3Ã5423Â ÃÂ 40-3-2 is as safe as non-GM soybeans.
⺠Stacked GM soybean 3Ã5423 Ã 40-3-2 contains elevated oleic acid relative to conventional soy and glyphosate tolerance. ⺠The subchronic study of 3Ã5423 Ã 40-3-2 was conducted. ⺠No adverse effect was observed in the rats consumed stacked GM soybean. ⺠Stacked GM soybean 3Ã5423 Ã 40-3-2 is as safe as conventional non-GM soybean.
Journal: Food and Chemical Toxicology - Volume 50, Issue 9, September 2012, Pages 3256-3263