PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K-Akt-MDM2 signaling suppression

► Diosmin inhibits cell proliferation through PP2A activation in HA22T cells in vitro. ► Diosmin caused no cytotoxicity in normal Chang liver cells. ► Diosmin dramatically suppressed tumor cell proliferation in nude mice model.