کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5852702 | 1130852 | 2012 | 5 صفحه PDF | دانلود رایگان |

In this study, we aimed to investigate the effects of vitamin U (Vit U) on valproic acid (VPA)-induced liver damage. Female Sprague Dawley rats were randomly divided into four groups. Group I was intact control animals. Group II was control rats given Vit U (50Â mg/kg/day) for fifteen days. Group III was given only VPA (500Â mg/kg/day) for fifteen days. Group IV was given VPAÂ +Â Vit U (in same dose and time). Vit U was given to rats by gavage and VPA was given intraperitoneally. On the 16th day of experiment, all the animals were fasted overnight and then sacrificed under ether anesthesia. Liver tissue was taken from animals, homogenized in 0.9% saline to make up to 10% homogenate. Liver aspartate and alanine transaminases, alkaline phosphatase, lactate dehydrogenase, myeloperoxidase, sorbitol dehydrogenase, glutamate dehydrogenase and xanthine oxidase activities and lipid peroxidation levels were increased and paraoxonase activity and glutathione levels were decreased in VPA group. Treatment with Vit U reversed these effects. These results demonstrated that administration of Vit U is a potentially beneficial agent to reduce the liver damage in VPA induced hepatotoxicity, probably by decreasing oxidative stress.
⺠Vitamin U protects against hepatotoxicity induced by VPA in rat. ⺠Liver AST, ALT, ALP, LDH, MPO, SDH, GLDH, XO activities and LPO level were increased. ⺠PON activity and GSH level were decreased in VPA group. ⺠Treatment with Vit U reversed these effects. ⺠Vit U is beneficial for the hepatic detoxification.
Journal: Food and Chemical Toxicology - Volume 50, Issue 10, October 2012, Pages 3562-3566