High-fructose corn syrup causes vascular dysfunction associated with metabolic disturbance in rats: Protective effect of resveratrol

► HFCS consumption caused vascular and metabolic dysfunction in rats. ► HFCS decreased endothelial relaxation, aortic nitric oxide and SIRT1. ► HFCS increased aortic gp91phox and p22phox. ► Resveratrol has a protective potential against consequences of HFCS consumption.