Safety evaluation of EvesseTM EPC, an apple polyphenol extract rich in flavan-3-ols

► We examined the safety of EvesseTMEPC, an apple polyphenol extract rich in epicatechin. ► Evesse™EPC showed positive responses in two in vitro genotoxicity studies. ► Evesse™EPC was negative in three in vivo genotoxicity studies studies. ► Therefore, Evesse™EPC was not of human health concern with respect to genotoxicity. ► The NOAEL in a 90-day study in rats was 2% in the diet (⩾1.3 g EvesseTMEPC/kg bw/day).