کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5854074 1130874 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A subacute toxicity evaluation of green tea (Camellia sinensis) extract in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
A subacute toxicity evaluation of green tea (Camellia sinensis) extract in mice
چکیده انگلیسی

Green tea is believed to be beneficial to health because it possesses antioxidant, antiviral and anticancer properties. The potential toxicity of green tea when administered at high doses via concentrated extracts, however, has not been completely investigated. The objective of the present study was to evaluate the safety of green tea extract in ICR mice using a subacute exposure paradigm. In this study, mice were orally administered (gavage) green tea extract at doses of 0 (as normal group), 625, 1250 and 2500 mg/kg body weight/day for 28 days. The results showed that oral administration of green tea extract did not cause adverse effects on body weight, organ weights, hematology, serum biochemistry, urinalysis or histopathology. Additionally, administering green tea extract via gavage significantly reduced triglyceride and cholesterol levels. These observed effects could be attributed to the high levels of catechins present in green tea as these compounds have been reported to have beneficial health effects. The no-observed-adverse-effect level for green tea extract derived from the results of the present study was 2500 mg/kg body weight/day.

► Evaluate the safety of green tea extract in ICR mice using a subacute exposure paradigm. ► Oral administration of green tea extract did not cause adverse effects. ► Administering green tea extract via gavage reduced triglyceride and cholesterol levels. ► The no-observed-adverse-effect level for green tea extract derived from the present study was 2500 mg/kg body weight/day.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 49, Issue 10, October 2011, Pages 2624-2630
نویسندگان
, , , , ,