کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5854351 | 1130901 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparison of rat olfactory mucosal responses to carcinogenic and non-carcinogenic chloracetanilides
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کلمات کلیدی
MMPCy5SDSCy3FDRSSCPMSFMin - حداقلdays - روزهاsodium dodecyl sulfate - سدیم دودسیل سولفاتcyanine-5 - سیانین -5Cyanine-3 - سیانین-3Phenylmethanesulfonyl fluoride - فنیل متیل سولفونیل فلورایدmatrix metalloproteinase - ماتریکس متالوپروتئینازOlfactory mucosa - مخاط بینیfalse discovery rate - میزان کشف کاذبpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Comparison of rat olfactory mucosal responses to carcinogenic and non-carcinogenic chloracetanilides Comparison of rat olfactory mucosal responses to carcinogenic and non-carcinogenic chloracetanilides](/preview/png/5854351.png)
چکیده انگلیسی
Alachlor and butachlor are chloracetanilide herbicides that induce olfactory tumors in rats, whereas propachlor does not. The mechanism by which alachlor induces tumors is distinct from many other nasal carcinogens, in that alachlor induces a gradual de-differentiation of the olfactory mucosa (OM) to a more respiratory-like epithelium, in contrast to other agents that induce cytotoxicity, followed by an aberrant regenerative response. We studied biochemical and genomic effects of these compounds to identify processes that occur in common between alachlor- and butachlor-treated rats. Because we have previously shown that matrix metalloproteinase-2 (MMP2) is activated in OM by alachlor, in the present studies we evaluated both MMP2 activation and changes in OM gene expression in response to carcinogenic and non-carcinogenic chloracetanilide treatments. All three chloracetanilides activated MMP2, and >300 genes were significantly up- or downregulated between control and alachlor-treated rats. The most significantly regulated gene was vomeromodulin, which was dramatically upregulated by alachlor and butachlor treatment (>60-fold), but not by propachlor treatment. Except for similar gene responses in alachlor- and butachlor-treated rats, we did not identify clear-cut differences that would predict OM carcinogenicity in this study.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 47, Issue 6, June 2009, Pages 1051-1057
Journal: Food and Chemical Toxicology - Volume 47, Issue 6, June 2009, Pages 1051-1057
نویسندگان
M.B. Genter, B.M. Warner, M. Medvedovic, M.A. Sartor,