کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5854419 | 1130901 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of green tea catechin on embryo/fetal development in rats
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کلمات کلیدی
GTCFDANOAELMHLWOECDGRASgenerally recognized as safe - به طور کلی به عنوان امن شناخته شده استTeratology - تراتولوژیEmbryonic development - رشد رویانgestation day - روز بارداریFood and Drug Administration - سازمان غذا و داروOrganization for Economic Co-operation and Development - سازمان همکاری و توسعه اقتصادیToxicity - سمی بودنICH - منno-observed-adverse-effect level - هیچ عارضه ای مشاهده نشدGreen tea catechins - کاکتیشین چای سبزGreen tea catechin - کاکتیشین چای سبزInternational Conference on Harmonization - کنفرانس بین المللی هماهنگی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of green tea catechin on embryo/fetal development in rats Effects of green tea catechin on embryo/fetal development in rats](/preview/png/5854419.png)
چکیده انگلیسی
Evidence suggests that the health benefits associated with green tea consumption are related to tea catechins. The objective of this study was to evaluate potential maternal and fetal effects of standardized heat-sterilized green tea catechins (GTC-H). GTC-H was gavage administered to mated female rats from gestation day 6 through 17, at doses of 0, 200, 600, and 2000Â mg/kg/day. There were no GTC-H-related deaths or macroscopic findings. During the entire gestation period in the high-dose (2000Â mg/kg/day)-treated group and during days 6-9 and 6-18 in the 600Â mg/kg/day group, mean body weight gain was lower. Mean feed consumption was lower during gestation days 6-9 in the 600Â mg/kg/day group and during gestation days 6-9 and 9-12 in the 2000Â mg/kg/day group. Compared to the control group, mean body weights in the 600 and 2000Â mg/kg/day groups were up to 5.1% and 7.7% lower during gestation days 9-20. GTC-H administration did not affect mean gravid uterine weights or intrauterine growth and survival. There were no GTC-H-related fetal malformations or developmental variations. Based on the results of this study, the no-observed-adverse-effect level (NOAEL) for GTC-H was 200Â mg/kg/day for maternal toxicity, and 2000Â mg/kg/day for embryo/fetal development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 47, Issue 6, June 2009, Pages 1296-1303
Journal: Food and Chemical Toxicology - Volume 47, Issue 6, June 2009, Pages 1296-1303
نویسندگان
Osamu Morita, John F. Knapp, Yasushi Tamaki, Donald G. Stump, John S. Moore, Mark D. Nemec,