کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5854614 1561893 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ratio of cord to maternal serum PCB concentrations in relation to their congener-specific physicochemical properties
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Ratio of cord to maternal serum PCB concentrations in relation to their congener-specific physicochemical properties
چکیده انگلیسی
The aim was to characterize placental transfer of some congeners of polychlorinated biphenyls (PCBs) and to relate human in utero exposure to these pollutants to their physicochemical properties. We included into the study 1134 births during the period 2002-2003 from two highly PCB contaminated districts in eastern Slovakia. Concentrations of 15 PCB congeners (IUPAC No. 28, 52, 101, 123+149, 118, 114, 153, 105, 138+163, 167, 156+171, 157, 180, 170, and 189) in umbilical cord (C) and maternal serum (M) were determined. The C/M ratios were significantly related, either positively or inversely depending on parameter, to the logarithm of partition coefficient octanol-water (KOW), to fusion enthalpy at the melting point, molecular weight, water solubility, total surface area of the molecule, solvent accessible surface area, melting point, molar volume, and molecular electronegativity distance vector. We found an inverse association between log KOW and lipid adjusted log C/M (const = 1.078, b1 = −0.179, p < 0.001, R2 = 0.039). Parameters evaluated were interrelated except fusion enthalpy at the melting point and electron affinity vs. solubility. We discuss the possible role of cholesterol as a transplacental transporter of PCBs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Hygiene and Environmental Health - Volume 218, Issue 1, January 2015, Pages 91-98
نویسندگان
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