کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5854678 | 1562042 | 2016 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neurobehavioral alterations plus transcriptional changes of the heat shock protein 90 and hypoxia inducible factor-1α in the crucian carp exposed to copper
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کلمات کلیدی
ventral telencephalonmRNAACSHSP90AMPAHIF-1αCarassius carassiusα-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acidVCEtorus longitudinalis - longitudinalis torusAnxiety-like behaviors - رفتارهای اضطراب مانندRecovery - ریکاوریTLo - زمینOptic tectum - سقف نوریDIG - شماHypoxia inducible factor-1alpha - فاکتور القای القای هیپوکسیCopper - مسNDLI - من هستمHeat shock protein 90 - پروتئین شوک حرارت 90optical density - چگالی نوری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Neurobehavioral alterations plus transcriptional changes of the heat shock protein 90 and hypoxia inducible factor-1α in the crucian carp exposed to copper Neurobehavioral alterations plus transcriptional changes of the heat shock protein 90 and hypoxia inducible factor-1α in the crucian carp exposed to copper](/preview/png/5854678.png)
چکیده انگلیسی
The various physiological alterations caused by copper (Cu) exposure in fish have attracted great interests toward neuronal strategies against Cu toxicity. Here, neurobehavioral activities (including anxiety-like behaviors) and transcriptional levels of heat shock protein (Hsp)90 and hypoxia inducible factor-1alpha (HIF-1α) were evaluated in the crucian carp (Carassius carassius) treated with nominal sub-lethal higher (1.45 mg/L) and lower (0.30 mg/L) concentrations of CuCl2. Both concentrations accounted for diminished swimming speed and food intake plus a strong preference for the dark side of the light/dark apparatus together with a reduction of crossings between the two compartments with respect to controls. Contextually, Hsp90 and HIF-1α transcripts were largely down- and up-regulated, respectively, in some brain areas such as in the medial part of the dorsal telencephalon (Dm, â52%) and in the ventral part of the ventral telencephalon (Vv, +68%). When carps were transferred to CuCl2-free water, some behaviors were rescued especially for fish previously exposed to 0.30 mg/L concentration. In this same condition, Hsp90 mRNA levels were recuperated (â94%) in the medial preglomerular nucleus (NPGm) with respect to exposed fish while HIF-1α mRNA was mostly down-regulated in telencephalic stations. Moreover, recovery capacities of this extraordinary resistant fish was exhibited by evident reductions (â80%) of the dark argyrophilic granules such as in the ventral telencephalon (VTel). Overall, our results point to interesting responses against Cu toxicity involving Hsp90 and HIF-1α transcripts that may constitute early indicators of environmental stressors leading to the repair of metal-induced damages in fish with notable brain plasticity properties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 52, January 2016, Pages 162-175
Journal: NeuroToxicology - Volume 52, January 2016, Pages 162-175
نویسندگان
Merylin Zizza, Marcello Canonaco, Rosa Maria Facciolo,