کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5854798 1562041 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Full length articleAssociations between prenatal mercury exposure and early child development in the ALSPAC study
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Full length articleAssociations between prenatal mercury exposure and early child development in the ALSPAC study
چکیده انگلیسی


- Prenatal blood mercury was measured in >2000 women linked their offspring's development at 4 time points.
- Adjusted associations indicated that the higher the level of blood mercury the more advanced the child's development.
- Adjustment of the analyses for blood selenium did not alter the results.
- Separate analyses of women who consumed or did not consume fish produced similar results.
- There was no indication that child development is harmed by the levels of mercury we studied (up to the EPA's RFD).

IntroductionThere is evidence that high levels of mercury exposure to the pregnant woman can result in damage to the brain of the developing fetus. However there is uncertainty as to whether lower levels of the metal have adverse effects on the development of the infant and whether components of fish consumption and/or the selenium status of the woman is protective.MethodsIn this study we analysed data from the Avon Longitudinal Study of Parents and Children (ALSPAC) (n = 2875-3264) to determine whether levels of total blood mercury of pregnant women collected in the first half of pregnancy are associated with the development of the offspring at ages 6, 18, 30 and 42 months. The developmental measures used maternal self-reported scales for individual types of development (fine and gross motor, social and communication skills) and total scores. Multiple and logistic regression analyses treated the outcomes both as continuous and as suboptimal (the lowest 15th centile). The statistical analyses first examined the association of prenatal mercury exposure with these developmental endpoints and then adjusted each for a number of social and maternal lifestyle factors; finally this model was adjusted for the blood selenium level.ResultsTotal maternal prenatal blood mercury and selenium ranged from 0.17 to 12.76 and 17.0 to 324 μg/L respectively. We found no evidence to suggest that prenatal levels of maternal blood mercury were associated with adverse development of the child, even when the mother had consumed no fish during pregnancy. In general, the higher the mercury level the more advanced the development of the child within the range of exposure studied. For example, the fully adjusted effect sizes for total development at 6 and 42 months were +0.51 [95%CI +0.05, +1.00] and +0.43 [95%CI +0.08, +0.78] points per SD of mercury. For the risk of suboptimal development the ORs at these ages were 0.90 [95%CI 0.80, 1.02] and 0.88 [95%CI 0.77, 1.02]. In regard to the associations between blood mercury and child development there were no differences between the mothers who ate fish and those who did not, thus implying that the benefits were not solely due to the beneficial nutrients in fish.ConclusionsWe found no evidence of adverse associations between maternal prenatal blood mercury and child development between 6 and 42 months of age. The significant associations that were present were all in the beneficial direction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 53, March 2016, Pages 215-222
نویسندگان
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