کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5854968 | 1562053 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Consequences of developmental exposure to concentrated ambient ultrafine particle air pollution combined with the adult paraquat and maneb model of the Parkinson's disease phenotype in male mice
ترجمه فارسی عنوان
پیامدهای قرارگیری در معرض آلودگی هوا به ذرات محیطی فوقالعاده متمرکز شده با مدل پاراکوات و مانعب از فنوتیپ بیماری پارکینسون در موشهای نر
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Current evidence suggests suceptibility of both the substantia nigra and striatum to exposure to components of air pollution. Further, air pollution has been associated with increased risk of PD diagnsosis in humans or PD-like pathology in animals. This study examined whether exposure of mice to concentrated ambient ultrafine particles (CAPS; <100Â nm diameter) during the first two weeks of life would alter susceptibility to induction of the Parkinson's disease phenyotype (PDP) in a pesticide-based paraquat and maneb (PQÂ +Â MB) model during adulthood utilizing i.p. injections of 10Â mg/kg PQ and 30Â mg/kg MB 2Ã per week for 6 weeks. Evidence of CAPS-induced enhancement of the PQÂ +Â MB PDP was limited primarily to delayed recovery of locomotor activity 24 post-injection of PQÂ +Â MB that could be related to alterations in striatal GABA inhibitory function. Absence of more extensive interactions might also reflect the finding that CAPS and PQÂ +Â MB appeared to differentially target the nigrostriatal dopamine and amino acid systems, with CAPS impacting striatum and PQÂ +Â MB impacting dopamine-glutamate function in midbrain; both CAPS and PQÂ +Â MB elevated glutamate levels in these specific regions, consistent with potential excitotoxicity. These findings demonstrate the ability of postnatal CAPS to produce locomotor dysfunction and dopaminergic and glutamateric changes, independent of PQÂ +Â MB, in brain regions involved in the PDP.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 41, March 2014, Pages 80-88
Journal: NeuroToxicology - Volume 41, March 2014, Pages 80-88
نویسندگان
Joshua L. Allen, Xiufang Liu, Douglas Weston, Katherine Conrad, Günter Oberdörster, Deborah A. Cory-Slechta,