NMR-based metabonomic in hippocampus, nucleus accumbens and prefrontal cortex of methamphetamine-sensitized rats

► We model sensitized rats with methamphetamine. ► We investigate the metabolic changes in three brain regions by NMR based metabonomic. ► Methamphetamine treatment can cause obvious neurotransmitters disturbance. ► Methamphetamine can also cause oxidative stress and gliosis in brain.