Inducible protection of human astrocytoma 1321N1 cells against hydrogen peroxide and aldehyde toxicity by 7-hydroxycoumarin is associated with the upregulation of aldo-keto reductases

► AKR1C3 and AKR7A2 protect 1321N1 cells against carbonyl and oxidant toxicity. ► AKR1C, AKR7A2 and ALDH2 enzymes are inducible by H2O2 and 4-hydroxynonenal. ► AKR1C and AKR7A2 are inducible by 7-hydroxycoumarin. ► 7-Hydroxycoumarin treatment protects against hydrogen peroxide and 4-hydroxynenal toxicity.