Propensity of Selaginella delicatula aqueous extract to offset rotenone-induced oxidative dysfunctions and neurotoxicity in Drosophila melanogaster: Implications for Parkinson's disease

► SDAE modulates endogenous oxidative markers in Drosophila. ► SDAE elevates the endogenous activity levels of TR and GR. ► SDAE offsets ROT-induced lethality and locomotor deficits. ► SDAE attenuates ROT-induced oxidative impairments and mitochondrial dysfunction. ► SDAE modulates the DA depletion and cholinergic function.