Cognitive and histological disturbances after chlorpyrifos exposure and chronic Aβ(1-42) infusions in Wistar rats

► We study the interaction between beta-amyloid toxicity and acute chlorpyrifos. ► Beta-amyloid i.c.v. infusion reduce behavioural flexibity. ► Combined beta-amyloid infusion and chlorpyrifos treatment impair visual learning. ► Beta-amyloid infusion reduced MAP1A inmunoreactivity in prefrontal cortex and hippocampus. ► Chlorpyrifos reduce MAP2 inmunoreactivity in prefrontal cortex.