Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: Involvement of ACE2-Ang (1-7)-mas axis

► EAM progression involves endoplasmic reticulum stress and cardiomyocyte apoptosis. ► ACE2-Ang (1-7)-mas axis is modulated during this condition. ► Candesartan cilexetil prevented the progression of EAM to dilated cardiomyopathy. ► Candesartan cilexetil reversed the change in SERCA2 expression in DCM.