کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5882177 1149360 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original studyAssociation of Positive EBAG9 Immunoreactivity With Unfavorable Prognosis in Breast Cancer Patients Treated With Tamoxifen
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
Original studyAssociation of Positive EBAG9 Immunoreactivity With Unfavorable Prognosis in Breast Cancer Patients Treated With Tamoxifen
چکیده انگلیسی

IntroductionBreast cancer is primarily a hormone-dependent tumor that is regulated by the status of the estrogen and progesterone receptors. We previously identified EBAG9 as an estrogen-responsive gene in MCF-7 human breast carcinoma cells. Upregulation of EBAG9 expression has been observed in several malignant tumors such as advanced breast cancers, indicating that EBAG9 might contribute to tumor progression.Patients and MethodsIn the present study, we generated a monoclonal antibody against EBAG9, and then performed immunohistochemical analysis of EBAG9 expression in specimens obtained from breast cancer patients treated with tamoxifen as an adjuvant therapy.ResultsEBAG9 immunoreactivity was detected in the cytoplasm of breast cancer cells and was significantly elevated in breast cancer samples from patients who relapsed during or after adjuvant tamoxifen treatment. Positive EBAG9 immunoreactivity was significantly correlated with poor patient prognosis.ConclusionThese results suggest that EBAG9 expression in tumor regions is associated with an unfavorable prognosis in breast cancer patients treated with tamoxifen.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Breast Cancer - Volume 13, Issue 6, December 2013, Pages 465-470
نویسندگان
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