کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5883001 | 1149782 | 2015 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Risk Factors for Multiple Myeloma: A Systematic Review of Meta-Analyses
ترجمه فارسی عنوان
عوامل خطر برای مبتلایان به میلومی چندگانه: بازبینی سیستماتیک متاآنالیزها
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کلمات کلیدی
همهگیرشناسی، متاآنالیز، میلوما چندگانه، عوامل خطر، بررسی سیستماتیک،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیهوشی و پزشکی درد
چکیده انگلیسی
The epidemiology of multiple myeloma (MM) is an increasingly investigated field, with many controversies. This systematic review aims to synthesize meta-analyses examining risk factors for MM so as to provide a comprehensive, parsimonious summary of the current evidence. Eligible meta-analyses were sought in PubMed adopting a predefined algorithm, without any restriction of publication language; end-of-search date was October 10, 2014. The selection of eligible studies and data extraction were performed by working in pairs, independently and blindly to each other; in case of disagreement, consensus with the whole team was reached. Among the 22 ultimately included meta-analyses, 9 examined occupational factors, 4 assessed aspects of lifestyle (smoking, alcohol, body mass index), 5 evaluated the presence of other diseases, and 4 addressed genetic factors as potential risk factors of MM. A vast compendium of significant associations arose, including farming, occupation as a firefighter, occupation as a hairdresser, exposures to chemicals or pesticides, overweight and obesity, patterns of alcohol intake, pernicious anemia, ankylosing spondylitis, gene promoter methylation, and polymorphisms. In conclusion, MM is a multifactorial disease, encompassing a wide variety of risk factors that span numerous life aspects. Further accumulation of evidence through meta-analyses is anticipated in this rapidly growing field.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Lymphoma Myeloma and Leukemia - Volume 15, Issue 10, October 2015, Pages 563-577.e3
Journal: Clinical Lymphoma Myeloma and Leukemia - Volume 15, Issue 10, October 2015, Pages 563-577.e3
نویسندگان
Theodoros N. Sergentanis, Flora Zagouri, Gerasimos Tsilimidos, Anastasia Tsagianni, Melina Tseliou, Meletios A. Dimopoulos, Theodora Psaltopoulou,