کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5889130 1568136 2016 29 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Joint dysfunction and functional decline in middle age myostatin null mice
ترجمه فارسی عنوان
اختلال در عملکرد مشترک و کاهش عملکرد در موش های نئوپرمی میستاتین میانی
کلمات کلیدی
میستاتین، مفصل مچ پا، قدرت گرفتن، استقامت تردمیل، سن،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی
Since its discovery as a potent inhibitor for muscle development, myostatin has been actively pursued as a drug target for age- and disease-related muscle loss. However, potential adverse effects of long-term myostatin deficiency have not been thoroughly investigated. We report herein that male myostatin null mice (mstn−/−), in spite of their greater muscle mass compared to wild-type (wt) mice, displayed more significant functional decline from young (3-6 months) to middle age (12-15 months) than age-matched wt mice, measured as gripping strength and treadmill endurance. Mstn−/− mice displayed markedly restricted ankle mobility and degenerative changes of the ankle joints, including disorganization of bone, tendon and peri-articular connective tissue, as well as synovial thickening with inflammatory cell infiltration. Messenger RNA expression of several pro-osteogenic genes was higher in the Achilles tendon-bone insertion in mstn−/− mice than wt mice, even at the neonatal age. At middle age, higher plasma concentrations of growth factors characteristic of excessive bone remodeling were found in mstn−/− mice than wt controls. These data collectively indicate that myostatin may play an important role in maintaining ankle and wrist joint health, possibly through negative regulation of the pro-osteogenic WNT/BMP pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 83, February 2016, Pages 141-148
نویسندگان
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