کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5889219 1568138 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Osteoinduction of bone grafting materials for bone repair and regeneration
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Osteoinduction of bone grafting materials for bone repair and regeneration
چکیده انگلیسی


- Autograft is still the clinical “gold standard” for regeneration of bone defects.
- Autograft has major limitations such as limited supply and donor site morbidity.
- Osteoinductive bone grafting materials could match the performance of autograft.
- Osteoinductivity shown by biomaterials is very limited compared to BMPs.
- Current knowledge should be used for effective development of new biomaterials.

Regeneration of bone defects caused by trauma, infection, tumours or inherent genetic disorders is a clinical challenge that usually necessitates bone grafting materials. Autologous bone or autograft is still considered the clinical “gold standard” and the most effective method for bone regeneration. However, limited bone supply and donor site morbidity are the most important disadvantages of autografting. Improved biomaterials are needed to match the performance of autograft as this is still superior to that of synthetic bone grafts. Osteoinductive materials would be the perfect candidates for achieving this task.The aim of this article is to review the different groups of bone substitutes in terms of their most recently reported osteoinductive properties. The different factors influencing osteoinductivity by biomaterials as well as the mechanisms behind this phenomenon are also presented, showing that it is very limited compared to osteoinductivity shown by bone morphogenetic proteins (BMPs). Therefore, a new term to describe osteoinductivity by biomaterials is proposed. Different strategies for adding osteoinductivity (BMPs, stem cells) to bone substitutes are also discussed. The overall objective of this paper is to gather the current knowledge on osteoinductivity of bone grafting materials for the effective development of new graft substitutes that enhance bone regeneration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 81, December 2015, Pages 112-121
نویسندگان
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