کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5889656 1568145 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original Full Length ArticleChanges in vertebral bone marrow fat and bone mass after gastric bypass surgery: A pilot study★
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Original Full Length ArticleChanges in vertebral bone marrow fat and bone mass after gastric bypass surgery: A pilot study★
چکیده انگلیسی


- Caloric restriction paradoxically increases marrow fat in mice, and women with anorexia nervosa have high marrow fat.
- We hypothesized that marrow fat increases after Roux-en-Y gastric bypass (RYGB) surgery, as total body fat decreases.
- In 11 obese women, vertebral marrow fat content was measured before and 6 months after RYGB, using magnetic resonance spectroscopy.
- Among the 6 diabetic women, RYGB decreased marrow fat. Among the 5 nondiabetic women, there was no mean change.
- Future studies of marrow fat should take diabetes status into account and explore marrow fat and bone mass relationships further.

Bone marrow fat may serve a metabolic role distinct from other fat depots, and it may be altered by metabolic conditions including diabetes. Caloric restriction paradoxically increases marrow fat in mice, and women with anorexia nervosa have high marrow fat. The longitudinal effect of weight loss on marrow fat in humans is unknown. We hypothesized that marrow fat increases after Roux-en-Y gastric bypass (RYGB) surgery, as total body fat decreases. In a pilot study of 11 morbidly obese women (6 diabetic, 5 nondiabetic), we measured vertebral marrow fat content (percentage fat fraction) before and 6 months after RYGB using magnetic resonance spectroscopy. Total body fat mass declined in all participants (mean ± SD decline 19.1 ± 6.1 kg or 36.5% ± 10.9%, p < 0.001). Areal bone mineral density (BMD) decreased by 5.2% ± 3.5% and 4.1% ± 2.6% at the femoral neck and total hip, respectively, and volumetric BMD decreased at the spine by 7.4% ± 2.8% (p < 0.001 for all). Effects of RYGB on marrow fat differed by diabetes status (adjusted p = 0.04). There was little mean change in marrow fat in nondiabetic women (mean + 0.9%, 95% CI − 10.0 to + 11.7%, p = 0.84). In contrast, marrow fat decreased in diabetic women (− 7.5%, 95% CI − 15.2 to + 0.1%, p = 0.05). Changes in total body fat mass and marrow fat were inversely correlated among nondiabetic (r = − 0.96, p = 0.01) but not diabetic (r = 0.52, p = 0.29) participants. In conclusion, among those without diabetes, marrow fat is maintained on average after RYGB, despite dramatic declines in overall fat mass. Among those with diabetes, RYGB may reduce marrow fat. Thus, future studies of marrow fat should take diabetes status into account. Marrow fat may have unique metabolic behavior compared with other fat depots.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 74, May 2015, Pages 140-145
نویسندگان
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