کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5889801 1568148 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Periostin expression contributes to cortical bone loss during unloading
ترجمه فارسی عنوان
بیان پریستین باعث از بین رفتن استخوان های کورتیک در هنگام تخلیه می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی
In Postn+/+ mice (wildtype littermate), HU significantly decreased femur BMD, as well as trabecular BV/TV and thickness (Tb.Th). Cortical bone volume and thickness at the femoral midshaft, also significantly decreased. These changes were explained by an inhibition of endocortical and periosteal bone formation activity and correlated with a decrease of Postn expression and a consecutive increase in Sost early after HU. Whereas trabecular bone loss in Postn−/− mice was comparable to Postn+/+ mice, HU did not significantly alter cortical bone microstructure and strength in Postn−/− mice. Bone formation remained unchanged in these mice, as Sost did not increase in the absence of periostin. In contrast, changes in Dkk1, Rankl and Opg expression in response to HU were similar to Postn+/+ mice, indicating that changes in periostin expression were quite specifically related to changes in Sost. In conclusion, HU inhibits periostin expression, which in turn plays an important role in cortical bone loss through an increase in Sost. These results further indicate that periostin is an essential mediator of cortical bone response to mechanical forces (loading and unloading).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 71, February 2015, Pages 94-100
نویسندگان
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