کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5890094 | 1568155 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A multiscale analytical approach for bone remodeling simulations: Linking scales from collagen to trabeculae
ترجمه فارسی عنوان
رویکرد تحلیلی چند بعدی برای شبیه سازی تغییرات استخوانی: پیوند مقیاس از کلاژن به ترابکول
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کلمات کلیدی
چند منظوره، بازسازی استخوان، کسر حجم استخوان، کلاژن، مدل سازی تحلیلی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
چکیده انگلیسی
At each different level, the bone composition was modeled as a two-phase material which made it possible to: 1) find a closed-form solution for the energy-based mechanical stimulus sensed by the osteocytes and 2) describe the anisotropic elastic properties at higher levels as a function of the stiffness of the elementary components (collagen, hydroxyapatite and water) at lower levels. The accuracy of the proposed multiscale model of bone remodeling was tested first by comparing the analytical bone volume fraction predictions to those obtained from the corresponding μFE-based computational model. Differences between analytical and numerical predictions were less than 1% while the computational time was drastically reduced, namely by a factor of 1 million. In a further analysis, the effects of changes in collagen and hydroxyapatite volume fractions on the bone remodeling process were simulated, and it was found that such changes considerably affect the bone density at the millimeter scale. In fact, smaller tissue density induces remodeling activities leading to finally higher overall bone density. The multiscale analytical model proposed in this study potentially provides an accurate and efficient tool for simulating patient-specific bone remodeling, which might be of importance in particular for the hip and spine, where an accurate assessment of bone micro-architecture is not possible.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 64, July 2014, Pages 303-313
Journal: Bone - Volume 64, July 2014, Pages 303-313
نویسندگان
Michele Colloca, Romane Blanchard, Christian Hellmich, Keita Ito, Bert van Rietbergen,