کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5890203 1568153 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interrelation between external oscillatory muscle coupling amplitude and in vivo intramedullary pressure related bone adaptation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Interrelation between external oscillatory muscle coupling amplitude and in vivo intramedullary pressure related bone adaptation
چکیده انگلیسی


- ImP inductions under dynamic hydraulic stimulation (DHS) were positively proportional to the loading amplitudes.
- The mitigation effect of DHS on disuse trabecular bone was highly related to the loading amplitudes.
- This study provides valuable information for DHS loading optimization, and confirms the regulatory effect of DHS on local fluid dynamics.

Interstitial bone fluid flow (IBFF) is suggested as a communication medium that bridges external physical signals and internal cellular activities in the bone, which thus regulates bone remodeling. Intramedullary pressure (ImP) is one main regulatory factor of IBFF and bone adaptation related mechanotransduction. Our group has recently observed that dynamic hydraulic stimulation (DHS), as an external oscillatory muscle coupling, was able to induce local ImP with minimal bone strain as well as to mitigate disuse bone loss. The current study aimed to evaluate the dose dependent relationship between DHS's amplitude, i.e., 15 and 30 mmHg, and in vivo ImP induction, as well as this correlation on bone's phenotypic change. Simultaneous measurements of ImP and DHS cuff pressures were obtained from rats under DHS with various magnitudes and a constant frequency of 2 Hz. ImP inductions and cuff pressures upon DHS loading showed a positively proportional response over the amplitude sweep. The relationship between ImP and DHS cuff pressure was evaluated and shown to be proportional, in which ImP was raised with increases of DHS cuff pressure amplitudes (R2 = 0.98). A 4-week in vivo experiment using a rat hindlimb suspension model demonstrated that the mitigation effect of DHS on disuse trabecular bone was highly dose dependent and related to DHS's amplitude, where a higher ImP led to a higher bone volume. This study suggested that sufficient physiological DHS is needed to generate ImP. Oscillatory DHS, potentially induces local fluid flow, has shown dose dependence in attenuation of disuse osteopenia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 66, September 2014, Pages 178-181
نویسندگان
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