Quantification of lower leg arterial calcifications by high-resolution peripheral quantitative computed tomography

Quantification of lower leg arterial calcifications (LLAC) by HR-pQCT. A. Image rescaling from 82 μm to 246 μm isotropic voxel size. B. Automated detection of bone contours, approval by operator. C. Bone masking, gauss-filtering and automated detection of calcifications based on a dual-threshold seeding segmentation. D. Quantification of calcifications in mg hydroxy-apatite (mg HA) as product of the total calcified volume and the mean vascular calcification density.81