کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5890565 1153255 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Scaling relations between trabecular bone volume fraction and microstructure at different skeletal sites
ترجمه فارسی عنوان
مقیاس روابط بین کسر حجم استخوان ترککالر و ریزساختار در سایت های مختلف اسکلتی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی


- Three hundred forty-nine trabecular bone samples were harvested from different skeletal sites.
- Bone volume fraction and several microstructure parameters were calculated in each trabecular bone sample.
- The bone volume fraction-microstructure scaling relations showed only small site-differences and were independent of vertebral fracture status.
- The scaling relations showed a rather universal character for subjects aged 60-69, 70-79, and > 79 years.

In this study, we investigated the scaling relations between trabecular bone volume fraction (BV / TV) and parameters of the trabecular microstructure at different skeletal sites.Cylindrical bone samples with a diameter of 8 mm were harvested from different skeletal sites of 154 human donors in vitro: 87 from the distal radius, 59/69 from the thoracic/lumbar spine, 51 from the femoral neck, and 83 from the greater trochanter. μCT images were obtained with an isotropic spatial resolution of 26 μm. BV / TV and trabecular microstructure parameters (TbN, TbTh, TbSp, scaling indices (< > and σ of α and αz), and Minkowski Functionals (Surface, Curvature, Euler)) were computed for each sample. The regression coefficient β was determined for each skeletal site as the slope of a linear fit in the double-logarithmic representations of the correlations of BV / TV versus the respective microstructure parameter.Statistically significant correlation coefficients ranging from r = 0.36 to r = 0.97 were observed for BV / TV versus microstructure parameters, except for Curvature and Euler. The regression coefficients β were 0.19 to 0.23 (TbN), 0.21 to 0.30 (TbTh), − 0.28 to − 0.24 (TbSp), 0.58 to 0.71 (Surface) and 0.12 to 0.16 (<α>), 0.07 to 0.11 (<αz>), − 0.44 to − 0.30 (σ(α)), and − 0.39 to − 0.14 (σ(αz)) at the different skeletal sites. The 95% confidence intervals of β overlapped for almost all microstructure parameters at the different skeletal sites. The scaling relations were independent of vertebral fracture status and similar for subjects aged 60-69, 70-79, and > 79 years.In conclusion, the bone volume fraction-microstructure scaling relations showed a rather universal character.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 57, Issue 2, December 2013, Pages 377-383
نویسندگان
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