Enhancement of tibial regeneration in a rat model by adipose-derived stromal cells in a PLGA scaffold

► Autologous adipose-derived stromal cells (ASCs) seeded onto a PLGA scaffold enhances tibial regeneration. ► PLGA-ASC composite leads to increased biomechanical strength. ► PLGA-ASC composite promotes osteogenesis through enhancing angiogenesis in tibial defects.