Sclerostin levels and bone turnover markers in adolescents with anorexia nervosa and healthy adolescent girls

► Serum sclerostin is positively associated with bone turnover markers in healthy adolescent girls. ► The relationship between sclerostin and bone turnover markers is disrupted in adolescent girls with anorexia nervosa. ► Transdermal estradiol replacement in adolescent girls with anorexia nervosa does not change sclerostin levels despite improving bone mass.