Low magnitude mechanical signals mitigate osteopenia without compromising longevity in an aged murine model of spontaneous granulosa cell ovarian cancer

► Low intensity vibration (LIV) effects on bone were examined in mice prone to granulosa cell tumorigenesis. ► Exposure to LIV did not compromise longevity following 1 year of daily treatment. ► Bone preservation was evident in tibiae and vertebrae of LIV mice as compared to controls. ► MSCs were significantly lower in the bone marrow of LIV-treated animals and in those lacking pathology. ► Overall tumor incidence was lower in LIV mice, and involved fewer organs when disease was evident.