کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5890944 1153262 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Five-year fracture risk estimation in patients with Parkinson's disease
ترجمه فارسی عنوان
برآورد ریسک شکست پنج ساله در بیماران مبتلا به پارکینسون
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی


- We identified predictors for osteoporotic and hip fractures in patients with Parkinson's disease.
- We developed a model to estimate 5-year osteoporotic and hip fracture risks among patients with Parkinson's disease.
- After external validation the developed model may be useful in daily practice.

BackgroundPrevious studies have shown that patients with Parkinson's disease (PD) are at increased risk of fractures. However, no specific prediction model for fracture estimation among PD patients is currently available. Therefore, the aim of this study was to develop a simple score for estimating the 5-year osteoporotic and hip fracture risks among patients with PD.MethodsThe UK Clinical Practice Research Datalink (1987-2011) was used to identify incident PD patients. Cox proportional-hazards models were used to calculate the 5-year risks of osteoporotic and hip fracture among PD patients. The regression model was fitted with various risk factors for fracture and the final Cox model was converted into integer risk scores.ResultsWe identified 4411 incident PD patients without a history of osteoporotic treatment. The 5-year risks of osteoporotic and hip fracture were plotted in relation to the risk score. Risk scores increased with age, female gender, history of renal disease and history of dementia. The C-statistic, which is a parameter to test the internal validity of the model, was reasonable for the prediction of osteoporotic fracture (0.69) and hip fracture (0.73).ConclusionIn this study, we developed a simple model to estimate 5-year fracture risk among incident PD patients. It may be useful in daily practice after external validation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 56, Issue 2, October 2013, Pages 266-270
نویسندگان
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