Rats treated with AZD2858, a GSK3 inhibitor, heal fractures rapidly without endochondral bone formation

► The Wnt-signaling pathway, which includes GSK-3, is important in bone regeneration. ► The small molecule drug AZ2858 inhibits GSK-3. ► Oral administration of AZD2858 increases bone mineral density and content in rats. ► AZD2858 improves fracture healing by increasing the size and bone mineral content of the callus. ► AZD2858 is a potent bone anabolic drug candidate for enhancement of fracture healing.