Acute BMP2 upregulation following induction of ischemic osteonecrosis in immature femoral head

► BMP2 is upregulated in the articular cartilage following ischemic induction. ► Oxidative stress (i.e. SOD2-H2O2 axis) is responsible for the BMP2 upregulation. ► HIF1 is only partially involved in the BMP2 upregulation.