کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5891334 | 1153271 | 2013 | 8 صفحه PDF | دانلود رایگان |
ObjectivesTo determine biochemical, radiological and micro-architectural bone factors related to fragility fractures in idiopathic male osteoporosis (IMO) patients. IMO is a rare disorder characterized by low areal bone mineral density (aBMD) (Z-score < â 2) occurring in men after excluding secondary causes of low BMD.MethodsWe conducted a case-control study in 31 patients with fragility fracture (IMO F +) that had occurred after the age of 40 years and 37 without fracture (IMO F-). We first compared IMO group to 40 age-matched disease-free men. We measured aBMD and bone micro-architectural indices at distal radius and tibia sites with a HR-pQCT scan (XtremeCT) using standard and extended cortical analysis. Urine and blood samples were collected in order to determine the levels of bone-turnover markers and the potential determinant of bone fragility. Models of analysis of covariance, including age, height and weight as adjustment factors, were used to compare the groups.ResultsCompared to their controls, IMO patients showed marked disturbance of their microâarchitectural parameters at tibia and radius affecting both trabecular and cortical parameters. IMO F + subjects were significantly older than IMO F â subjects (58 ± 8 vs. 53 ± 9 yrs, p = 0.01). BMD Z-score at the total-hip was significantly lower in IMO F + (â 1.3 ± 0.5 vs. â 0.9 ± 0.8 g/cm2, p = 0.01). After adjustment, trabecular microâarchitectural parameters, biochemical markers and hormonal parameters were not different in the 2 groups. At distal tibia, cortical v-BMD was significantly lower in IMO F + patients (799 ± 73 vs. 858 ± 60 mg/cm3, p = 0.03), while cortical thickness was not different.ConclusionOur results show that patients with IMO display a marked disturbance of trabecular and cortical bone micro-architecture, and that age and low cortical density are determinants of the fracture occurrence.
⺠We conducted a case-control study in middle-aged men with idiopathic osteoporosis. ⺠We measured biochemical, radiological and micro-architectural bone factors. ⺠We compared men with and without fragility fracture after 40 yrs of age. ⺠Age and low cortical density are main determinants of the fracture occurrence.
Journal: Bone - Volume 52, Issue 1, January 2013, Pages 48-55