Effects of combined treatment with eldecalcitol and alendronate on bone mass, mechanical properties, and bone histomorphometry in ovariectomized rats: A comparison with alfacalcidol and alendronate

► The effects of combination treatments with eldecalcitol and alendronate or alfacalcidol and alendronate are examined in ovariectomized rats. ► Eldecalcitol with alendronate therapy inhibits bone resorption, while maintaining bone formation by histomorphometric analysis. ► Alfacalcidol with alendronate therapy inhibits the histological parameters of both bone resorption and formation. ► This study suggests eldecalcitol with alendronate therapy has therapeutic advantages over alfacalcidol with alendronate therapy.