The effect of CCL3 and CCR1 in bone remodeling induced by mechanical loading during orthodontic tooth movement in mice

► This study investigated the role of CCR1 and CCL3 in bone remodeling induced by mechanical loading in mice. ► Bone remodeling was significantly decreased in CCL3−/− and CCR1−/− mice and in animals treated with Met-RANTES. ► CCR1 is pivotal for bone remodeling induced by mechanical loading and these actions depend, at least in part, on CCL3.