Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice

► Daily injections of osteocalcin increase β-cell mass and insulin secretion. ► Daily injections of osteocalcin improve insulin sensitivity in a mouse model of type 2 diabetes. ► Daily injections of osteocalcin prevent obesity by increasing energy expenditure. ► Daily injections of osteocalcin prevent liver steatosis.