Lathyrism-induced alterations in collagen cross-links influence the mechanical properties of bone material without affecting the mineral

► Alterations in collagen cross-links have previously been reported in humans sustaining fracture. ► An animal model of lathyrism was employed. ► An array of analytical techniques was used to determine structural and material properties of bone. ► Even anatomically localized changes in collagen cross-links affect bone strength, independent of mineral characteristics.