JNK inhibitors increase osteogenesis in Nf1-deficient cells

► c-Jun N-terminal Kinase (JNK) signaling is over-activated in Nf1+/− osteoblasts. ► Nf1null osteoblasts showed increased total and activated c-Jun. ► JNK inhibition increased bone markers in rhBMP-2 treated cell lines. ► JNK inhibition increased bone markers in Nf1+/− and Nf1null osteoblasts.